REFUSEtoAGETM
NAD+ Supplement for Healthy Aging
REFUSEtoAGETM
Pharmacist-reviewed for Medication Interactions
$39.99 · 60 capsules · 30-day supply
Why NAD+ Matters as You Age
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme your body uses in hundreds of metabolic processes, from converting food into cellular energy to repairing damaged DNA. Your cells depend on it. But research measuring NAD+ in specific tissues like the brain and muscle suggests levels may decline significantly with age, which has been linked to reduced cellular energy, slower metabolism, and cognitive decline.
REFUSEtoAGE is designed to support your body's NAD+ levels with a formula that goes beyond a single ingredient. Rather than relying on nicotinamide riboside alone, it pairs NR with compounds that support NAD+ activation, cellular protection, and absorption, giving you a more complete approach to healthy aging support.
Key Ingredients
Nicotinamide Riboside (NR) — 500mg
The core of the formula. NR is a form of vitamin B3 that the body converts into NAD+. It's one of the most studied NAD+ precursors, and at 500mg per serving, REFUSEtoAGE delivers a clinically relevant dose.
Trans-Resveratrol — 150mg
A polyphenol found naturally in grape skins, resveratrol is included for its role in activating sirtuins — proteins involved in cellular repair, metabolism, and aging. Trans-resveratrol is the bioactive form, which matters because many supplements use the less effective form without disclosing it.
Quercetin — 150mg
A flavonoid found in onions, apples, and berries, quercetin supports cellular protection against oxidative stress and has senolytic properties — meaning it may help clear damaged cells that accumulate with age. It also supports the bioavailability of other ingredients in the formula.
Galactomannans
A prebiotic fiber included to support absorption of the other active ingredients. Many NAD+ supplements skip absorption support entirely, which can reduce how much of the active ingredients your body actually uses.
Who REFUSEtoAGE is Designed For
REFUSEtoAGE is formulated for adults who want to support cellular energy, metabolism, and cognitive health as they age*, particularly those who are already taking prescription medications and want an NAD+ supplement that's been evaluated for compatibility.
If you take medications for blood pressure, cholesterol, diabetes, or other chronic conditions, choosing an NAD+ supplement without knowing how the ingredients interact with your prescriptions means guessing. REFUSEtoAGE was designed so you don't have to.
*These statements have not be evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Pharmacist-Reviewed Medication Interaction Results
Every ingredient in REFUSEtoAGE has been evaluated individually by a registered pharmacist for potential interactions with commonly prescribed medications for the top health conditions outlined by the CDC. The results are published below — including the categories where we recommend you avoid this product.
We publish every result, not just the favorable ones. If REFUSEtoAGE isn't compatible with your medications, we'd rather you know before you buy. That's what pharmacist-reviewed means to us.
Because every individual’s health journey is unique, this information is not intended to be medical advice and we always recommend consulting your physician before starting any new medication, vitamin, or supplement.
How to Read This Table
Generally well receive — No widely reported interactions at typical supplement doses.
Consult your physician — Potential considerations exist; discuss with your healthcare provider before use.
Avoid — Known interaction risks that warrant avoiding this combination.
| Condition | Common Medications | Recommendation |
|---|---|---|
| High Blood Pressure | Diuretics, beta-blockers, ARBs | Generally well received |
| Obesity | Semaglutide (Wegovy, Ozempic), Saxenda, Zepbound | Consult your physician |
| High Cholesterol | Statins, Zetia, fibrates | Consult your physician |
| Arthritis | Corticosteroids, DMARDs, biologics | Avoid |
| Chronic Kidney Disease | ACE inhibitors, ARBs, SGLT2 inhibitors | Generally well received |
| Diabetes | Insulin, metformin, SGLT2, GLP-1 | Consult your physician |
| Depression | SSRIs, SNRIs, TCAs | Avoid |
| Asthma | Albuterol, inhaled corticosteroids, LABAs | Generally well received |
| Heart Disease | Statins, beta-blockers, aspirin | Consult your physician |
| COPD | SABAs, LABAs, ICS combos | Generally well received |
| Cancer | Anastrozole, doxorubicin, steroids, ondansetron | Avoid |
| Stroke | Anticoagulants, antiplatelets | Avoid |
| IBS / GERD / GI Conditions | PPIs, Lubiprostone (IBS-C), antacids | Generally well received |
| Menopause | HRT | Generally well received |
Reviewed by Sunny Chow, RPh — Registered Pharmacist
This review is for informational purposes only and does not constitute medical advice. Always consult your physician before starting any new supplement, especially if you take prescription medications.
Manufactured in the USA in GMP-certified and NSF-certified facilities
Independently third-party lab tested for purity and potency
Non-GMO, gluten-free, dairy-free, and vegetarian-friendly
No artificial flavors or colors
Certificate of Analysis available upon request at hello@ryosvitamins.com
Quality You Can Verify
What does REFUSEtoAGE do? REFUSEtoAGE is an NAD+ supplement designed to support cellular energy production, metabolism, and cognitive health as you age. It combines nicotinamide riboside (an NAD+ precursor) with trans-resveratrol, quercetin, and galactomannans — ingredients that support NAD+ activation, cellular protection, and absorption.
How is REFUSEtoAGE different from other NAD+ supplements? Two things set it apart. First, the formula pairs NR with complementary ingredients (resveratrol for sirtuin activation, quercetin for cellular protection, galactomannans for absorption) rather than relying on a single ingredient. Second, every ingredient has been pharmacist-reviewed for potential interactions with commonly prescribed medications and the results are published on this page so you can see them before you buy.
Can I take REFUSEtoAGE with my prescription medications? It depends on what you take. The interaction table above shows results across 14 medication categories. Some are generally well tolerated, some warrant a conversation with your physician, and some should be avoided. We always recommend reviewing your full medication list with your healthcare provider before starting any new supplement.
Why does the table say "Avoid" for some medications? Because transparency matters more to us than a sale. REFUSEtoAGE contains resveratrol and quercetin, which can affect liver enzymes involved in processing certain medications, particularly anticoagulants, some chemotherapy drugs, and arthritis treatments. Rather than hiding that information, we publish it so you can make an informed decision.
How do I take REFUSEtoAGE? Take two capsules daily, 20–30 minutes before a meal. Each bottle contains 60 capsules, a 30-day supply.
Where can I buy REFUSEtoAGE? REFUSEtoAGE is available exclusively on Amazon. Subscribe and Save is available for recurring delivery.