REFUSEtoAGETM
NAD+ Supplement for Healthy Aging
REFUSEtoAGETM
Pharmacist-reviewed for Medication Interactions
$39.99 · 60 capsules · 30-day supply
Why NAD+ Matters as You Age
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme your body uses in hundreds of processes, from turning food into cellular energy to repairing DNA. Research measuring NAD+ in tissues like muscle and brain suggests levels decline with age. Researchers have associated that decline with lower cellular energy and slower metabolism.
REFUSEtoAGE supports healthy NAD+ levels from three directions at once.* It supplies the building block your cells use to make NAD+, supports the proteins that put NAD+ to work, and helps protect the NAD+ you already have. Every ingredient was reviewed by our pharmacist, Sunny Chow, RPh, against 14 categories of commonly prescribed medications. The results are published on this page.
How It Works
Produce: 500mg niacinamide supplies the raw material for NAD+.*
Activate: Trans-resveratrol supports sirtuins, the NAD+-dependent proteins involved in cellular repair.*
Protect: Quercetin and alpha-lipoic acid help preserve NAD+ and support mitochondrial health.*
Key Ingredients
Nicotinamide (Vitamin B3) — 500mg
The foundation of the formula. Niacinamide is the form of vitamin B3 your cells recycle into NAD+ through the salvage pathway, the body’s main route for keeping NAD+ supplied. It is a small, stable molecule that absorbs well on its own. In published human research from Hamamatsu University, a single 500mg dose, the amount in REFUSEtoAGE, significantly raised blood NAD+ levels. It is also a non-flushing form of B3, unlike regular niacin.
Trans-Resveratrol — 150mg
A polyphenol from Japanese knotweed root, included to support sirtuins, the NAD+ dependent proteins involved in cellular repair and metabolism.* Trans-resveratrol is the biologically active form.
Quercetin — 150mg
A flavonoid from Sophora japonica flower. Laboratory research suggests quercetin can slow CD38, an enzyme that breaks down NAD+ and becomes more active with age. Quercetin also supports cellular defense against oxidative stress.*
Alpha-Lipoic Acid - 150mg
An antioxidant your mitochondria use to produce energy. It supports mitochondrial function and helps recycle other antioxidants, such as vitamins C and E.*
The Research Behind the Ingredients
Hamamatsu University, 2020 & 2021: Single-dose human studies of oral niacinamide, including the 500mg dose used in REFUSEtoAGE.
Sheridan et al., npj Aging, 2024: A human clinical trial of a multi-pathway approach that pairs an NAD+ precursor with sirtuin-supporting and NAD+-preserving compounds.
These studies examined the ingredients, not REFUSEtoAGE itself.
Who REFUSEtoAGE is Designed For
REFUSEtoAGE is for adults who:
want to support cellular energy, metabolism, and cognitive health as they age*
want to see exactly what’s in their supplement
want to know how it fits with the medications they already take
If you take medications for blood pressure, cholesterol, blood sugar, or another chronic condition, you shouldn’t have to guess how a supplement interacts with them. Sunny Chow, RPh, reviewed every ingredient in REFUSEtoAGE against 14 medication categories. You can see her results in the table below before you buy.
*These statements have not be evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Pharmacist-Reviewed Medication Interaction Results
Every ingredient in REFUSEtoAGE has been evaluated individually by a registered pharmacist for potential interactions with commonly prescribed medications for the top health conditions outlined by the CDC. The results are published below — including the categories where we recommend you avoid this product.
We publish every result, not just the favorable ones. If REFUSEtoAGE isn't compatible with your medications, we'd rather you know before you buy. That's what pharmacist-reviewed means to us.
Because every individual’s health journey is unique, this information is not intended to be medical advice and we always recommend consulting your physician before starting any new medication, vitamin, or supplement.
How to Read This Table
Generally well receive — No widely reported interactions at typical supplement doses.
Consult your physician — Potential considerations exist; discuss with your healthcare provider before use.
Avoid — Known interaction risks that warrant avoiding this combination.
| Condition | Common Medications | Recommendation |
|---|---|---|
| High Blood Pressure | Diuretics, beta-blockers, ARBs | Generally well received |
| Obesity | Semaglutide (Wegovy, Ozempic), Saxenda, Zepbound | Consult your physician |
| High Cholesterol | Statins, Zetia, fibrates | Consult your physician |
| Arthritis | Corticosteroids, DMARDs, biologics | Avoid |
| Chronic Kidney Disease | ACE inhibitors, ARBs, SGLT2 inhibitors | Generally well received |
| Diabetes | Insulin, metformin, SGLT2, GLP-1 | Consult your physician |
| Depression | SSRIs, SNRIs, TCAs | Avoid |
| Asthma | Albuterol, inhaled corticosteroids, LABAs | Generally well received |
| Heart Disease | Statins, beta-blockers, aspirin | Consult your physician |
| COPD | SABAs, LABAs, ICS combos | Generally well received |
| Cancer | Anastrozole, doxorubicin, steroids, ondansetron | Avoid |
| Stroke | Anticoagulants, antiplatelets | Avoid |
| IBS / GERD / GI Conditions | PPIs, Lubiprostone (IBS-C), antacids | Generally well received |
| Menopause | HRT | Generally well received |
Reviewed by Sunny Chow, RPh — Registered Pharmacist
This review is for informational purposes only and does not constitute medical advice. Always consult your physician before starting any new supplement, especially if you take prescription medications.
Manufactured in the USA in GMP-certified and NSF-certified facilities
Independently third-party lab tested for purity and potency
Non-GMO, gluten-free, dairy-free, and vegetarian-friendly
No artificial flavors or colors
Certificate of Analysis available upon request at hello@ryosvitamins.com
Quality You Can Verify
What does REFUSEtoAGE do?
REFUSEtoAGE is an NAD+ supplement that supports cellular energy, metabolism, and cognitive health as you age.* It combines 500mg niacinamide, the B3 building block of NAD+, with trans-resveratrol, quercetin, and alpha-lipoic acid. Together they support NAD+ production, activity, and protection.
What makes REFUSEtoAGE different?
Two things. First, it supports NAD+ from multiple pathways, with every dose on the label. Second, every ingredient has been reviewed by a pharmacist for interactions with commonly prescribed medications. The results are published on this page so you can see them before you buy.
Why niacinamide?
Niacinamide is the form of vitamin B3 your cells recycle into NAD+, and it absorbs well without special delivery technology. In published human research, a single 500mg dose, the same amount in REFUSEtoAGE, significantly raised blood NAD+ levels.
Will niacinamide make me flush?
No. Flushing comes from nicotinic acid (regular niacin). Niacinamide is a non-flushing form of B3.
Can I take REFUSEtoAGE with my prescription medications?
It depends on what you take. The table above shows results across 14 medication categories:
some are generally well tolerated
some warrant a conversation with your physician
some should be avoided
Review your full medication list with your healthcare provider before starting any new supplement.
Why does the table say “Avoid” for some medications?
Because transparency matters more to us than a sale. Ingredient can affect mechanism, e.g., liver enzymes or blood sugar involved with certain medications, particularly arthritis, depression, cancer, and stroke. Rather than hiding that information, we publish it so you can make an informed decision.
How do I take REFUSEtoAGE?
Take two capsules daily, 20–30 minutes before a meal, with an 8 fl. oz glass of water, or as directed by your healthcare professional. Each bottle contains 60 capsules, a 30-day supply.
Did the formula change?
Yes. In October 2026 we rebuilt REFUSEtoAGE around 500mg niacinamide, added alpha-lipoic acid for mitochondrial support, and increased quercetin to 150mg. Trans-resveratrol remains at 150mg. If your bottle lists nicotinamide riboside, it’s the earlier version and is fine to use through its expiration date. Our pharmacist reviewed the updated formula, and the table on this page reflects the current version.
Where can I buy REFUSEtoAGE?
REFUSEtoAGE is available exclusively on Amazon, with Subscribe & Save for recurring delivery.